主讲课程

本科生：《发酵工程》、《生物工艺学》、《生物资源学导论》、《专业论文写作与专业英语》、《生工类专业写作》

研究生：《生物炼制技术》、《学科科技英语写作》

个人简介

  章文明，博士，教授，硕士生导师，入选中国科协“青年人才托举工程”、江苏省“青蓝工程”优秀青年骨干教师，江苏省科技副总。担任Front Bioeng Biotech客座副主编和编委、《生物学杂志》编委。主要从事：1）C1化合物（甲醇、甲酸、二氧化碳）的高效生物转化；2）萜类等天然产物高效合成的酵母细胞工厂构建与调控；3）菌株抗逆性能提升的调控策略。

代表性成果

1.主持项目

国家自然科学基金面上项目，甲醇高效利用和转化的解脂耶氏酵母人工细胞构建及调控研究，2021.01-2024.12，主持

国家自然科学基金青年基金，甲醇驱动大肠杆菌高效合成琥珀酸的代谢工程，2018.01-2020.12，主持

国家重点研发计划，新天然与人工产物的定向挖掘和高效合成的平台技术，2020.01-2024.12，子课题负责人

国家重点研发计划，有机碳一原料高效利用和转化人工合成细胞的构建，2019.07-2024.06，子课题负责人

中国科协青年人才托举工程项目，合成生物与生物系统工程，2020.01-2022.12，主持

江苏省先进生物制造协同创新中心项目，甲醇驱动琥珀酸高效合成的代谢网络构建与调控，2018.03-2020.12，主持

省部共建生物催化与酶工程国家重点实验室开放课题，碳一原料高效联产油脂与蛋白生物合成体系的构建与调控，2021.12-2023.12，主持

企业合作项目，高产虾青素的饲用酵母开发与应用，2021.12-2023.12，主持

企业合作项目，生物法合成丁二酸技术，2022.01-2024.04，技术负责人

2. 发表论文、专利、论著

以第一/通讯作者在国内外学术刊物上发表论文40余篇，其中3篇被选为封面论文；研究成果发表在生物工程领域权威期刊Trends in Biotechnology、Biotechnology Advances、Green Chemistry、ACS Synthetic Biology、Biotechnology and Bioengineering等。以第一发明人申请中国发明专利10项，授权2项（1项已技术转让）。参编教材《微生物与人类》、《生物质利用原理与技术》、《生物资源学导论》；参编专著《非粮生物质炼制技术》、译著《图解生物技术》、2部英文专著章节。

3. 代表性论文

1. Wenming Zhang* et al. Thermophiles: potential chassis for lignocellulosic biorefinery. Trends in Biotechnology, 2022, 40:6.

2. Wenming Zhang*, et al. Advances in the synthesis of three typical tetraterpenoids including β-carotene, lycopene and astaxanthin. Biotechnology Advances. 2022; 61, 108033.

3. Dan Wu, Wenming Zhang, Baihe Fu*, Zhonghai Zhang*. Living intracellular inorganic-microorganism biohybrid system for efficient solar hydrogen generation. Joule, 2022, 10: 2293-2303.

4. Wenming Zhang*, et al. Biotechnological applications of the non-conventional yeast Meyerozyma guilliermondii. Biotechnology Advances. 2021, 46, 107674.

5. Wenming Zhang*, et al. Biofilm application in the microbial biochemicals production process. Biotechnology Advances, 2021, 107724.

6. Wenming Zhang*, et al. Improving methanol assimilation in Yarrowia lipolytica via systematic metabolic engineering combined with compartmentalization. Green Chemistry, 2022, accepted.

7. Wenming Zhang*, et al. Spatial niche construction for consortium-based consolidated bioprocessing system. Green Chemistry. 2022; 24, 7941.

8. Wenming Zhang*, et al. Increased lipid production in Yarrowia lipolytica from acetate through metabolic engineering and co-substrates fermentation. ACS Synthetic Biology. 2021; 10, 3129-3138.

9. Wenming Zhang*, et al. The de novo synthesis of 2-phenylethanol from glucose by the synthetic microbial consortium composed of engineered Escherichia coli and Meyerozyma guilliermondii. ACS Synthetic Biology. 2022; accepted.

10. Wenming Zhang, et al. Metabolic engineering of Escherichia coli for high yield production of succinic acid driven by methanol. ACS Synthetic Biology, 2018, 7(12):2803-2811.

11. Wenming Zhang*, et al. Metabolic engineering of Pichia pastoris for malic acid production from methanol. Biotechnology and Bioengineering. 2021,118:357–371.

12. Wenming Zhang*, et al. Microbial co-culturing of Chlorella sp. and Rhodotorula toruloides for the enhanced microbial lipid production. Fuel, 2022, 124609.

13. Wenming Zhang*, et al. Bioconversion of volatile fatty acids into lipids by the oleaginous yeast Apiotrichum porosum DSM27194, Fuel, 2021, 290, 119811.

14. Wenming Zhang, et al. Expression of global regulator IrrE for improved succinate production under high salt stress by Escherichia coli. Bioresource Technology, 2018, 254, 151-156.

15. Wenming Zhang*, et al. Comprehensive evaluation for the one-pot biosynthesis of butyl acetate by using microbial mono- and co-cultures. Biotechnology for Biofuels, 2021, 14:203.

16. Wenming Zhang, et al. Current advance in bioconversion of methanol to chemicals. Biotechnology for Biofuels, 2018, 11(1), 260.

17. Wenming Zhang*, et al. Improved succinic acid production through the reconstruction of methanol dissimilation in Escherichia coli. Bioresources and Bioprocessing, 2022, 9:62.

18. Wenming Zhang*, et al. Efficient fatty acid synthesis from methanol in methylotrophic yeast. Synthetic and Systems Biotechnology. 2022, 7: 1183–1184.

19. Wenming Zhang*, et al. Strategies to improve the stress resistance of Escherichia coli in industrial biotechnology. Biofuels, Bioproducts and Biorefining-Biofpr. 2022, 16:1130–1141.

20. Wenming Zhang, et al. Adaptive evolution improves acid tolerance and succinic acid production in Actinobacillus succinogenes. Process Biochemistry, 2020, 98:76-82.

21. Wenming Zhang*, et al. Valorization of crude glycerol into citric acid and malic acid by Yarrowia lipolytica. Industrial & Engineering Chemistry Research. 2020, 59(39), 17165–17172.

22. Wenming Zhang et al. Metabolic regulation of organic acid biosynthesis in Actinobacillus succinogenes. Frontiers in Bioengineering and Biotechnology, 2019, 7, 216.

23. 章文明*，等. 一碳资源在酵母中的利用与转化. 化工进展, 2022.

24. 章文明*，等.合成生物学及其研究进展. 生物学杂志, 2020, 37 (5):1-9.